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KMID : 0043319830060010035
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Archives of Pharmacal Research
1983 Volume.6 No. 1 p.35 ~ p.44
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Studies on the Interaction of Thiamines and Cyclodextrins
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Im IS
Lee WK/Park MK/Kim BK
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Abstract
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Interactions between thiamine.HCl and its disulfide derivatives TTFD, TPD and alpha-, beta-cyclodextrins were investigated. By measuring the 1H-NMR, 13C-NMR chemical shifts, the assumption that cyclodextrin may form a inclusion complex with thiamines was supported qualitatively. To calculate the stability constants of them, anion exchange chromatography was applied. The simple, rapid HPLC method was proved to be pertinent thiamine/cyclodextrin system which was chemically unstable and less soluble.
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